0 Climate ChangeAdaptation and Disaster Risk Reduction in Europe A Review of Risk Governance this will result in a battle at the end of the round, and the outcome of the battle will determine who controls that territory and its contents. The DHPC will also be published on a dedicated page on the EMA website.Picato is available as a gel which is applied to skin areas affected by actinic keratosis. h�bbd```b``� "�@$S;�d+��'��/��u0)"Y$���d��m`��M�&���`�N��f��ؘ "SOIƀb ��#���`��ȿ�710120� e����� �� In this article, we investigate the case of non-US institutions, with several factors explaining the dynamics of financial firms returns and with asynchronicity of time zones. Disputed Territories. %%EOF EMA is in the process of making appropriate changes to this website. The review of Picato has been initiated at the request of the European Commission, under Article 20 of Regulation (EC) No 726/2004. A systematic review was conducted of published reports of risk factors associated with MDR‐TB in Europe. h�ܗms�8���>��k�ڞa:��z���8��H�ԃcgl迿]� 5M��_��,�v%���*8X�9�R2,\b��0 EMA is recommending that patients stop using Picato (ingenol mebutate), a gel for treating the skin condition actinic keratosis, while it continues its review of the medicine’s safety.While uncertainties remain, there is concern about a possible link between the use of Picato and the development of skin cancer. h�b```�i�D@��������㤃"����_����3�[��v����@ε�Y�71.^ 1��x�t��{����"}�.�H1rpg鞜7�sۭ��Llw�=(=��t�B�;U@��ۅ/dsO����rqP={tȄ;��r0t04D ! We find that, for certain countries, the cost for the taxpayer to rescue the riskiest domestic banks is so high that some banks might be considered too big to be saved.Most users should sign in with their email address. �ϻ����6{�_������ի���O��� �� �k��*����m� ��x �m 8� �M����~Zlj"|�n"δ"��&_(���{���i�/Sm��k Kä!��)a1mH.f��9��Trԣp G�J ��ƈTq��uq��c�&���2i1��+1�BcELJ��gR�T�`R�H��B��FQE3��_��~�^��+.���,��_c�y6��I���U��g��Q{����`�g����j�O��?d-BB�K��dzv������d�zÏo�u��3�U�z�6��]����.M�o�M��K���g�,�'��x���_9��l����l�h5�j��X��y7b9E���1��i�;�Q^,m PRIMO: This approach and methodology of Risk Management Partners and Gallagher Basset can result in a systematic and thorough picture of the actual health and safety aspects in a public organisation. endstream endobj startxref We apply this methodology to the 196 largest European financial firms and estimate their systemic risk over the 2000–12 period. It is used when the outer layer of the affected skin is not thickened or raised. Notwithstanding the heterogeneity of the populations studied and measures of incidence rates used, overall the annual incidence was 1.07–1.7 per 1000 population. endstream endobj 872 0 obj <> endobj 873 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>>>/Shading<>/XObject<>>>/Rotate 0/StructParents 0/TrimBox[0.0 0.0 595.276 841.89]/Type/Page>> endobj 874 0 obj <>stream For Permissions, please email: journals.permissions@oup.com.You do not currently have access to this article.You could not be signed in. {GCSEcV�#�9��@�O [3����@��]����0�3�0�X1�3H�`�c��@ڀA�Ay��lSdD0�9 �Ex�.��f�BR��p�����Ono]�2��&��:K� ���Z#u �����n�3b>G�o=�_�����q���퀈��{�(c���t�>j?�_�������w�x'�6�Lo���G�뇔�ǔ��)������=����ۧ��DKa��:F�1����!f����}d"�^$� ��fj��I�� If the site still contains content that does not yet reflect the withdrawal of the UK from the EU, this is unintentional and will be addressed.Article 20 of Regulation (EC) No 726/2004,Pharmacovigilance Risk Assessment Committee,Committee for Medicinal Products for Human Use,Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 13-16 January 2020.There is concern about a link between the use of Picato and the development of skin cancer.Patients should no longer use Picato gel to treat actinic keratosis while authorities review the data.Patients should look out for any unusual skin changes or growths and seek medical advice promptly if any occur.If you have any questions, you should speak with your doctor.The final results of a three-year study in 484 patients showed a higher incidence of skin malignancy with ingenol mebutate than with the comparator imiquimod (3.3% of patients developed cancer in the Picato group versus 0.4% in the comparator group).A higher incidence of skin tumours occurred in the ingenol mebutate arm of an 8-week vehicle-controlled trial in 1,262 patients (1% of patients in the ingenol mebutate arm versus 0.1% in the vehicle arm).Healthcare professionals should stop prescribing Picato and consider different treatment options, while authorities review the data.Healthcare professionals should advise patients to be vigilant for any skin lesions developing and to seek medical advice promptly should any occur.EMA continues its review of the available data and will provide further information when the review concludes.

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